Hate to put it on one guys shoulders, but it all comes down to IC's ribs. We'll have RS back, but he doesn't have the cut ability to make up for two O-linemen being out, where Crowell has the ability to cut behind the line and turn a 2 yard loss into a 2 to 3 yard gain.
If he's healthy enough for 20 to 30 touches (carries and recpetions) and can be affective with the touches he gets, we win. If not, we might be in trouble...